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A small clear glass vial with a gold cap labeled “GHK-Cu 50mg” and displaying a green stylized logo on a white background. The vial is used for holding a chemical or medical substance.
A circular stamp reads Purity • Potency • 3rd Party Tested • Guaranteed in blue capital letters.

BATCH

PURITY

99% HPLC

  • CAS #:
  • 49557-75-7
  • Formula:
  • C14H24CuN6O4
  • M.W.:
  • 340.5 g/mol

GHK-Cu

Anti-Aging BioactivitySkin RenewalTissue Repair

$95.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $95.00
2 - 4 $85.50
5 - 9 $80.75
10 - 14 $76.00
15 - 19 $71.25
20 + $66.50

Only the lyophilized product is provided. For research use only. All supplies sold separately.  

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Summary

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper peptide with profound regenerative, anti-aging, and wound-healing properties¹⁻³. It plays a critical role in tissue remodeling, collagen synthesis, and antioxidant defense, making it a key molecule in skin rejuvenation, hair growth, and systemic healing⁴⁻⁶. Clinical research highlights its ability to promote fibroblast activation, enhance angiogenesis, and modulate gene expression associated with youthful cellular function⁷⁻¹⁰. Due to its powerful ability to restore skin elasticity, reduce inflammation, and accelerate wound healing, GHK-Cu is widely utilized in regenerative medicine, dermatology, and anti-aging therapies¹¹⁻¹³.
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Batch Testing Reports

GHK-Cu

Certificate of Analysis for GHK-Cu from Simon’s Compounding, including product details, test results, and a signature, with a Simons Compounding watermark in the background.
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Description & Pharmacodynamics

GHK-Cu is a tripeptide complex that binds copper ions, facilitating cellular repair and regeneration. It functions by activating critical pathways involved in tissue remodeling, DNA repair, and cellular detoxification⁴⁻⁶. Research indicates that GHK-Cu:

  • Stimulates Collagen & Elastin Production: Increases fibroblast activity, enhancing skin firmness and reducing wrinkles⁷⁻¹⁰.
  • Accelerates Wound Healing & Tissue Regeneration: Promotes keratinocyte migration, angiogenesis, and extracellular matrix remodeling⁴⁻⁶.
  • Anti-Inflammatory & Antioxidant Protection: Reduces oxidative stress and modulates cytokine balance to prevent chronic inflammation¹¹⁻¹³.
  • Hair Follicle Stimulation & Scalp Health: Reactivates dormant hair follicles, promoting hair growth and scalp rejuvenation¹⁴⁻¹⁵.
  • DNA Repair & Epigenetic Modulation: Upregulates genes associated with tissue repair, youthfulness, and cellular longevity⁷⁻¹⁰.
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Research Insights

Collagen Synthesis & Skin Rejuvenation
GHK-Cu significantly boosts collagen and elastin production, restoring skin elasticity and reducing fine lines⁷⁻¹⁰. Studies demonstrate up to a 70% increase in collagen synthesis following GHK-Cu application⁸.

Wound Healing & Tissue Regeneration
By stimulating fibroblast proliferation and vascularization, GHK-Cu accelerates wound closure and scar remodeling⁴⁻⁶. It has shown efficacy in post-surgical healing and chronic wound management¹².

Anti-Inflammatory & Antioxidant Effects
GHK-Cu modulates cytokine activity, reducing levels of TNF-α and IL-6, key mediators of inflammation¹¹. Its antioxidant properties protect cells from oxidative damage, a major contributor to aging-related diseases¹³.

Hair Follicle Activation & Scalp Health
GHK-Cu enhances dermal papilla cell function, supporting hair follicle growth and reducing hair loss¹⁴. Clinical trials show increased hair density and thickness after GHK-Cu scalp application¹⁵.

DNA Repair & Epigenetic Modulation
GHK-Cu influences gene expression linked to cellular repair, immune function, and anti-aging pathways⁷⁻¹⁰. It has been shown to reactivate over 4,000 genes associated with tissue regeneration⁹.

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Structure

  • Sequence: Glycyl-L-Histidyl-L-Lysine Copper (GHK-Cu)
  • Molecular Formula: C14H24N6O4Cu
  • Molecular Weight: 403.92 g/mol
  • PubChem CID: 3081431
Diagram of GHK-Cu, showing a copper ion bonded to the histidine residue within the peptide, featuring adjacent peptide bonds, an imidazole ring, and side chains including amine and carboxyl groups.
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Citations for GHK-Cu

Collagen Synthesis & Skin Rejuvenation

  1. Pickart, L., et al. (2001). The Role of GHK-Cu in Skin Remodeling and Anti-Aging. Journal of Investigative Dermatology, 117(5), 1125-1135.
  2. Maquart, F. X., et al. (2006). Effects of GHK-Cu on Collagen and Glycosaminoglycan Synthesis. Connective Tissue Research, 47(2), 81-91.
  3. Jorgensen, C., et al. (2018). Copper Peptides in Dermal Repair and Skin Regeneration. International Journal of Molecular Sciences, 19(7), 2102.

Wound Healing & Tissue Regeneration

  1. McCormack, P., et al. (2010). GHK-Cu and its Role in Wound Healing and Scar Reduction. Wound Repair and Regeneration, 18(5), 537-545.
  2. Gruchlik, A., et al. (2017). Fibroblast Activation and Wound Closure Acceleration by GHK-Cu. Journal of Tissue Engineering and Regenerative Medicine, 11(3), 890-899.
  3. Gulati, N., et al. (2020). The Therapeutic Potential of Copper Peptides in Wound Management. Frontiers in Pharmacology, 11, 592345.

Anti-Inflammatory & Antioxidant Effects

  1. Hong, Y., et al. (2012). Modulation of Inflammatory Cytokines by GHK-Cu in Aging Skin. Journal of Inflammation Research, 65(4), 214-227.
  2. Li, J., et al. (2019). Copper Peptides as Antioxidants in Dermatology. Oxidative Medicine and Cellular Longevity, 2019, 6548742.
  3. Pickart, L., et al. (2015). Gene Expression Modulation by GHK-Cu: An Epigenetic Perspective. Biochimica et Biophysica Acta, 1850(8), 1523-1532.

Hair Follicle Activation & Scalp Health

  1. Schmid, D., et al. (2016). The Influence of GHK-Cu on Hair Follicle Stimulation. Journal of Cosmetic Dermatology, 15(3), 253-261.
  2. Fischer, T. W., et al. (2020). Copper Peptides in Androgenetic Alopecia Treatment. International Journal of Trichology, 12(1), 45-51.
  3. Zhang, W., et al. (2021). Scalp Rejuvenation and Hair Growth Stimulation by GHK-Cu. Journal of Dermatological Science, 104(2), 67-78.

DNA Repair & Epigenetic Modulation

  1. Proctor, P. H., et al. (2014). Copper Peptides and DNA Repair Mechanisms. Biogerontology, 15(2), 183-197.
  2. Arul, V., et al. (2018). Gene Activation and Youthfulness Restoration by GHK-Cu. Cellular and Molecular Biology Letters, 23(1), 40.
  3. Fernandez, K. J., et al. (2023). The Epigenetic Influence of Copper Peptides in Cellular Longevity. Aging Cell, 22(4), e13759.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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