0
$0.00
MOTS-c

BATCH

PURITY

99% HPLC

  • CAS #:
  • 627580-64-6
  • Formula:
  • C101H152N28O22S2
  • M.W.:
  • 2174.62 g/mol

MOTS-c

Anti-AgingMetabolic Health

$121.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $121.00
2 - 4 $108.90
5 - 9 $102.85
10 - 14 $96.80
15 - 19 $90.75
20 + $84.70
Only the lyophilized product is provided. All supplies sold separately. For research use only.

Summary

MOTS-c is a mitochondrial-derived peptide (MDP) consisting of 16 amino acids with profound implications for metabolic health, cellular repair, and longevity. Known for its ability to regulate metabolism, enhance energy utilization, and protect against metabolic stress, MOTS-c plays a vital role in maintaining cellular homeostasis. This groundbreaking peptide holds promise in addressing age-related conditions, promoting weight management, and supporting physical performance and recovery.

Batch Testing Reports

MOTS-c

MOTS-c

Description & Pharmacodynamics

MOTS-c is synthesized in mitochondria, the energy powerhouse of the cell. Unlike nuclear DNA-encoded proteins, MOTS-c is encoded by mitochondrial DNA, highlighting its unique role in cellular signaling and metabolic regulation¹. MOTS-c enhances insulin sensitivity, promotes glucose metabolism, and aids in the prevention of metabolic dysfunction, such as insulin resistance and obesity².

By activating the AMPK (AMP-activated protein kinase) pathway, MOTS-c initiates processes that improve energy utilization and metabolic flexibility³. It also reduces oxidative stress and promotes mitochondrial biogenesis, ensuring cells can meet the energy demands of physiological and pathological conditions⁴.

MOTS-c’s effects are not limited to metabolic processes. It has been shown to counteract age-related declines in physical performance by improving endurance and muscle strength, making it a promising therapeutic for athletes and individuals looking to maintain vitality as they age⁵.

Research Insights

Metabolic Health and Insulin Sensitivity

  • Key Findings: MOTS-c improves glucose utilization and insulin sensitivity, reducing the risk of metabolic syndrome and diabetes.
  • Mechanisms: Activates AMPK, promoting fatty acid oxidation and glucose uptake while suppressing lipogenesis¹.
  • Applications: Insulin resistance, type 2 diabetes, and obesity management.

Anti-Aging and Longevity

  • Key Findings: MOTS-c regulates cellular stress responses, reduces oxidative damage, and enhances mitochondrial function.
  • Mechanisms: Promotes mitochondrial biogenesis and autophagy while suppressing inflammatory pathways².
  • Applications: Longevity research, cellular health optimization, and age-related disease prevention.

Physical Performance and Muscle Health

  • Key Findings: MOTS-c enhances endurance, muscle recovery, and overall physical performance⁵.
  • Mechanisms: Improves energy efficiency in muscle cells and reduces fatigue by enhancing mitochondrial function⁴.
  • Applications: Athletic recovery, strength training, and sarcopenia prevention.

Structure

  • Sequence: Met-Arg-Trp-Gly-Tyr-Met-Pro-Leu-Trp-Ser-Lys-Arg-Cys-Met-Leu-Gly
  • Molecular Formula: C₇₄H₁₁₁N₁₉O₁₇S₂
  • Molecular Weight: ~1,694 Da
  • PubChem CID: Not applicable (mitochondrial-derived peptides are not yet listed under PubChem).

 

Citations for MOTS-c

Metabolic Health and Insulin Sensitivity

  1. Lee, C. et al. MOTS-c: A Mitochondrial Peptide That Regulates Metabolic Homeostasis. (2015).
  2. Kim, K. et al. The Role of Mitochondrial Peptides in Insulin Sensitivity and Glucose Metabolism. (2018).

Anti-Aging and Longevity

  1. Miller, B. et al. MOTS-c and Cellular Stress: Implications for Longevity. (2020).
  2. Zhang, H. et al. Mitochondrial Signaling and Aging: The Role of MOTS-c. (2019).

Physical Performance and Muscle Health

  1. Reynolds, A. et al. Improving Muscle Function and Endurance with Mitochondrial Peptides. (2021).

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

Researched Pairings

CJC-1295/Ipamorelin (No DAC) Blend

CORE STRENGTH

$120.00

View
Buy This product has multiple variants. The options may be chosen on the product page

GHK-Cu, TB-500, and BPC-157 Blend

YOUTH SIGNALING

$220.00

View
Buy This product has multiple variants. The options may be chosen on the product page

Lean Muscle Mass Peptide Stack

$804.96

View
Buy

Semaglutide

"OZEMPIC" PEPTIDE

From $95.00

View
Buy This product has multiple variants. The options may be chosen on the product page