Cagrilintide
Weight Loss | Metabolic Efficiency | Glucose Regulation | Appetite Reshaping
Cagrilintide, a synthetic analogue of the natural hormone amylin, has shown promising potential in supporting weight loss and improving metabolic health. Clinical studies highlight its effectiveness in obesity management, with weight reduction of 6–11% of body weight achieved over 20 weeks when administered weekly (1, 2). When combined with semaglutide, the results are even more significant, demonstrating weight loss of up to 17% of body weight in the same period (1, 2). By targeting appetite regulation, glucose control, and energy balance, cagrilintide may represent an important step forward in managing obesity, type 2 diabetes, and related metabolic conditions (1, 3).
*Only the lyophilized product is provided.
Weight Loss | Metabolic Efficiency | Glucose Regulation | Appetite Reshaping
Cagrilintide, a synthetic analogue of the natural hormone amylin, has shown promising potential in supporting weight loss and improving metabolic health. Clinical studies highlight its effectiveness in obesity management, with weight reduction of 6–11% of body weight achieved over 20 weeks when administered weekly (1, 2). When combined with semaglutide, the results are even more significant, demonstrating weight loss of up to 17% of body weight in the same period (1, 2). By targeting appetite regulation, glucose control, and energy balance, cagrilintide may represent an important step forward in managing obesity, type 2 diabetes, and related metabolic conditions (1, 3).
*Only the lyophilized product is provided.
Weight Loss | Metabolic Efficiency | Glucose Regulation | Appetite Reshaping
Cagrilintide, a synthetic analogue of the natural hormone amylin, has shown promising potential in supporting weight loss and improving metabolic health. Clinical studies highlight its effectiveness in obesity management, with weight reduction of 6–11% of body weight achieved over 20 weeks when administered weekly (1, 2). When combined with semaglutide, the results are even more significant, demonstrating weight loss of up to 17% of body weight in the same period (1, 2). By targeting appetite regulation, glucose control, and energy balance, cagrilintide may represent an important step forward in managing obesity, type 2 diabetes, and related metabolic conditions (1, 3).
*Only the lyophilized product is provided.
Research Insights
Obesity
Weight Loss Outcomes: Clinical trials demonstrate weight loss of 6–11% over 20 weeks with cagrilintide alone (1). When paired with semaglutide, weight loss can reach up to 17% of body weight during the same timeframe (1, 2).
Caloric Regulation: By enhancing satiety and reducing hunger, cagrilintide supports sustainable dietary adjustments (1).
Type 2 Diabetes
Improved Glycemic Control: Cagrilintide reduces hemoglobin A1C by up to 2.2%, improves insulin sensitivity, and decreases glucagon levels, contributing to better glucose management (3).
Pancreatic Benefits: Its actions help protect and preserve pancreatic function, minimizing strain on insulin production (3).
Cardiovascular Health
Risk Reduction: Through weight reduction and improved metabolic parameters, cagrilintide may help reduce cardiovascular risks commonly associated with obesity and type 2 diabetes (1, 3).
Liver Health
Liver Support: Preliminary research suggests benefits in conditions like non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease due to its role in reducing adiposity and improving metabolic regulation (5).
Neurodegenerative Conditions
Potential for Cognitive Health: Amylin-related peptides, including cagrilintide, are being explored for their potential role in addressing Alzheimer’s disease and other neurodegenerative conditions, although this remains an area of emerging research (4).
Description & Pharmacodynamics
Cagrilintide works by enhancing the body's natural mechanisms for appetite control and energy regulation. As an analogue of amylin, it is designed to be more stable and long-acting, overcoming some of the limitations of the natural peptide (6, 7). Its mechanisms include:
Promoting Satiety: Activates receptors in the brain to enhance feelings of fullness, helping to naturally reduce food intake (1, 2).
Slowing Gastric Emptying: Extends digestion time, leading to more gradual nutrient absorption and improved blood sugar stability (1, 3).
Regulating Glucagon: Decreases glucagon secretion, which helps prevent excessive conversion of glucose into fat (3).
Enhanced Stability: Modifications to its structure improve its efficacy and half-life, allowing for once-weekly dosing (6).
These effects, in combination, support weight management and glycemic control in patients with obesity and type 2 diabetes (1, 3).
Structure
Sequence: [Details of amino acid sequence]
Molecular Formula: C₂₂₈H₃₆₆N₆₄O₆₆S₂
Molecular Weight: ~5,074 Da
PubChem CID: 171397054
Citations
Obesity
Lau, D. C. W., et al. Once-weekly cagrilintide for weight management in people with overweight and obesity.Lancet, 2021. DOI: 10.1016/S0140-6736(21)01751-7.
Enebo, L. B., et al. Safety, tolerability, pharmacokinetics, and pharmacodynamics of cagrilintide with semaglutide.Lancet, 2021. DOI: 10.1016/S0140-6736(21)00845-X.
Type 2 Diabetes
Frias, J. P., et al. Efficacy and safety of cagrilintide with semaglutide in type 2 diabetes. Lancet, 2023. DOI: 10.1016/S0140-6736(23)01163-7.
Neurodegenerative Research
Qiu, W. Q., et al. Association between amylin and amyloid-β peptides. PLoS One, 2014. DOI: 10.1371/journal.pone.0088063.
Liver Disease
Bailey, C. J., et al. Peptide-based therapies for obesity and type 2 diabetes. Peptides, 2024. DOI: 10.1016/j.peptides.2024.171149.
General References
Kruse, T., et al. Development of Cagrilintide, a Long-Acting Amylin Analogue. J. Med. Chem., 2021. DOI: 10.1021/acs.jmedchem.1c00565.
Pittner, R. A., et al. Molecular physiology of amylin. Journal of Cellular Biochemistry, 1994. DOI: 10.1002/jcb.240550004.
