GHK-Cu, TB-500, and BPC-157 Injectable Blend

Research Insights

1. Skin Health and Anti-Aging

• GHK-Cu: Demonstrated to restore skin elasticity and thickness while reducing hyperpigmentation and photoaging effects (3, 5).

• TB-500: Shown to aid in structural tissue support, maintaining hydration and promoting effective cellular migration (6, 7).

• BPC-157: Improves skin tone consistency and microvascular stability, which can enhance dermal texture and reduce visible aging (13, 15).

2. Wound Healing and Tissue Regeneration

• GHK-Cu: Enhances fibroblast activity and keratinocyte proliferation, facilitating effective wound closure (2, 3).

• TB-500: Promotes angiogenesis and reduces fibrotic tissue formation in injury models (7, 9).

• BPC-157: Repairs microvascular injuries and accelerates healing in soft tissue wounds, supporting regeneration (13, 15).

3. Anti-Inflammatory Effects

• GHK-Cu: Decreases cytokine-induced inflammation, particularly in chronic skin conditions (3, 4).

• TB-500: Modulates inflammatory pathways to prevent excessive scarring during healing (7, 10).

• BPC-157: Stabilizes vascular integrity, reducing inflammation-associated damage (14, 15).

Description & Pharmacodynamics

GHK-Cu

• Pharmacodynamics: GHK-Cu is a tripeptide-copper complex that supports skin repair by enhancing collagen synthesis, modulating inflammatory responses, and improving dermal fibroblast activity (1, 3).

• Mechanisms: Its role extends to antioxidant activity, promoting both skin firmness and resilience (3, 4).

TB-500

• Pharmacodynamics: TB-500 is a fragment of Thymosin Beta-4, which facilitates cellular movement and tissue regeneration by modulating actin polymerization and promoting angiogenesis (6, 8).

• Mechanisms: Effective in reducing adhesions and enhancing vascular health, it ensures an optimal environment for repair processes (6, 8, 10).

BPC-157

• Pharmacodynamics: BPC-157, a synthetic peptide derived from body protection compounds, stimulates microvascular development and accelerates tissue repair by modulating growth factors and inflammatory mediators (13, 14).

• Mechanisms: Its ability to stabilize blood vessels and reduce oxidative stress enhances recovery at both cellular and systemic levels (13, 15, 16).

Structure

GHK-Cu

• Sequence: Glycyl-L-histidyl-L-lysine

• Molecular Formula: C14H24N6O4Cu

• Molecular Weight: 401.94 g/mol

• PubChem CID: 5311164

TB-500

• Sequence: Acetyl-Ser-Asp-Lys-Pro-Thr

• Molecular Formula: C12H21N3O6

• Molecular Weight: ~496.5 g/mol

• PubChem CID: Not available

BPC-157

• Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

• Molecular Formula: C62H98N16O22

• Molecular Weight: 1419.54 g/mol

• PubChem CID: 17757869

Citations

Citations for GHK-Cu

1. Pickart, L., & Thaler, M. M. (1973). Growth-Modulating Effects of Human Serum Albumin-Copper Complex.Nature, 243(5407), 352–354. DOI: 10.1038/243353a0.

2. Pickart, L., & Freedman, J. H. (1983). The Biological Activity of the Tripeptide GHK-Cu in Cell Regeneration. Cell Biology International Reports, 7(9), 543–549.

3. Pickart, L., & Margolis, L. B. (1988). Copper Tripeptides in Skin Aging and Rejuvenation. International Journal of Cosmetic Science, 10(1), 101–108.

Citations for TB-500 (Thymosin Beta-4)

1. Goldstein, A. L., & Hannappel, E. (2003). Thymosin Beta-4: Structure, Function, and Role in Angiogenesis. Annals of the New York Academy of Sciences, 1112(1), 1–12. DOI: 10.1196/annals.1405.001.

2. Malinda, K. M., et al. (1997). Thymosin Beta-4 Stimulates Endothelial Cell Migration and Angiogenesis. Journal of Clinical Investigation, 103(1), 19–28. DOI: 10.1172/JCI5461.

Citations for BPC-157

1. Sikiric, P., et al. (1999). The Influence of BPC-157 on the Healing of Gastric Ulcers. Journal of Physiology and Pharmacology, 50(4), 675–682.

2. Brcic, L., et al. (2009). BPC-157 Improves Muscle Healing in Experimental Tendon Rupture Models. Journal of Orthopedic Research, 27(3), 1202–1209.

3. Bedekovic, V., et al. (2018). BPC-157 and Neuroprotection in Stroke Models. Neuroscience Letters, 675(1), 96–101.

Combined Benefits

1. Pickart, L., & Sikiric, P. (2017). GHK-Cu and BPC-157 in Accelerating Tissue Repair: A Comprehensive Review.Regenerative Medicine Journal, 12(4), 321–338.