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PT-141 (Bremelanotide)

BATCH

PURITY

99% HPLC

  • CAS #:
  • 189691-06-3
  • Formula:
  • C50H68N14O10
  • M.W.:
  • 1025.16 g/mol

PT-141 (Bremelanotide)

All Gender Sexual Arousal

$110.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $110.00
2 - 4 $99.00
5 - 9 $93.50
10 - 14 $88.00
15 - 19 $82.50
20 + $77.00
Only the lyophilized product is provided. All supplies sold separately. For research use only.

Summary

PT-141 (Bremelanotide) directly enhances sexual desire and arousal in all genders by activating melanocortin receptors in the brain. Unlike vascular-targeting therapies such as phosphodiesterase inhibitors (e.g., Viagra), PT-141 bypasses the circulatory system and focuses on central nervous system pathways, making it a groundbreaking treatment for hypoactive sexual desire disorder (HSDD) in women and erectile dysfunction (ED) in men (1, 2, 3). Clinical trials highlight its efficacy, with a 30% success rate in men unresponsive to sildenafil and significant improvement in satisfying sexual experiences for women with HSDD (2, 3). Delivered as a nasal spray, PT-141 offers rapid absorption and ease of use, positioning it as a versatile and innovative therapy for sexual dysfunction and beyond.

Description & Pharmacodynamics

PT-141 acts primarily through melanocortin-4 receptor (MC4R) and melanocortin-1 receptor (MC1R) activation:

  • MC4R Activation: Regulates sexual arousal by modulating pathways in the hypothalamus, directly influencing libido and satisfaction (1, 2).
  • MC1R Activation: Provides systemic effects, including tissue protection during ischemic events and potential roles in immune modulation (4).

Combination Therapy
When combined with phosphodiesterase inhibitors like sildenafil or tadalafil, PT-141 enhances blood flow, improves erectile function, and sustains arousal, particularly for patients with incomplete responses to conventional treatments (3).

Non-Sexual Applications

  • Hemorrhagic Shock: By activating MC1R and MC4R, PT-141 mitigates ischemic damage and supports tissue recovery in low-oxygen conditions (4).
  • Immune Modulation: Demonstrates anti-inflammatory properties and potential efficacy against drug-resistant fungal infections (4, 5).
  • Metabolic Research: Activation of melanocortin pathways highlights its potential in addressing obesity and metabolic syndrome (5).

Research Insights

Sexual Disfunction
  • Men: A 30% success rate was observed in achieving erections sufficient for intercourse among men unresponsive to sildenafil (1).
  • Women: Improved frequency of satisfying sexual experiences and reduced sexual distress scores in premenopausal women with HSDD (2).
Combination Therapy Benefits
  • Enhanced arousal and sustained erectile function when used with phosphodiesterase inhibitors (3).
Hemorrhagic Shock
  • PT-141 reduced ischemic tissue damage and promoted recovery in preclinical models of hemorrhagic shock (4).
Immune Modulation
  • Exhibits anti-inflammatory properties and potential use in fungal infections resistant to current antifungals (4).
Cancer Research
  • Activation of MC1R may influence DNA repair pathways, reducing the risk of basal and squamous cell carcinoma (6).
6. Metabolic and Neurological Applications
  • Research into melanocortin pathways indicates potential in treating early-onset obesity and metabolic syndrome linked to MC4R mutations (5).

Structure

  • Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
  • Molecular Formula: C50H68N14O10
  • Molecular Weight: 1025.2 g/mol
  • PubChem CID: 9941679

Citations for PT-141 (Bremelanotide)

Sexual Dysfunction
  1. Rosen, R. C., et al. Evaluation of the effects of subcutaneous PT-141 in male ED patients unresponsive to Viagra.Int. J. Impot. Res., 2004.
  2. Clayton, A. H., et al. Bremelanotide for female sexual dysfunction in premenopausal women. Women’s Health, 2016.
  3. Safarinejad, M. R., & Hosseini, S. Y. Efficacy of Bremelanotide in sildenafil non-responders. J. Urol., 2008.
Immune Modulation and Hemorrhagic Shock
  1. Ji, H., et al. Anti-inflammatory effects of melanocortin analogs. PLOS ONE, 2013.
Metabolic and Neurological Applications
  1. Spana, C., et al. Metabolic and thermogenic implications of melanocortin agonists. Diabetes Obes. Metab., 2022.
Cancer Research
  1. Maresca, V., et al. Skin phototype and implications of melanocortin pathways in cancer. Pigment Cell Melanoma Res., 2015.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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