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Semaglutide

BATCH

PURITY

99% HPLC

  • CAS #:
  • 910463-68-2
  • Formula:
  • C187H291N45O59
  • M.W.:
  • 4113.58 g/mol

Semaglutide

Appetite ReshapingGlucose RegulationMetabolic EfficiencyWeight Loss

From $95.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $95.00
2 - 4 $85.50
5 - 9 $80.75
10 - 14 $76.00
15 - 19 $71.25
20 + $66.50
Only the lyophilized product is provided. All supplies sold separately. For research use only.

Summary

​​Semaglutide is a synthetic analogue of the naturally occurring glucagon-like peptide-1 (GLP-1), which plays a critical role in regulating glucose metabolism, appetite, and energy balance1,2. As the active ingredient in groundbreaking therapies like Ozempic, Wegovy, and others, Semaglutide has transformed the treatment landscape for diabetes and obesity. In clinical trials, individuals receiving Semaglutide achieved weight loss of up to 15% of total body weight over 68 weeks when combined with lifestyle interventions2,3. Its mechanisms extend beyond glucose control, offering cardiovascular and neuroprotective benefits, as well as appetite regulation for both food and alcohol. By optimizing metabolic and systemic functions, Semaglutide supports patients in taking the most challenging yet crucial first step toward reclaiming their health and vitality.

Batch Testing Reports

Semaglutide

Semaglutide

Description & Pharmacodynamics

Mechanisms of Action

  1. Glucose Regulation: Enhances insulin secretion in a glucose-dependent manner while suppressing glucagon release, reducing hepatic glucose production, and stabilizing blood sugar levels (1, 3).
  2. Appetite Suppression and Weight Loss: By activating GLP-1 receptors in the hypothalamus and brainstem, Semaglutide increases satiety, slows gastric emptying, and reduces caloric intake (2, 3).
  3. Beta Cell Protection: Promotes pancreatic beta cell growth, proliferation, and protection from apoptosis, supporting insulin production and pancreatic health (4).
  4. Cardiovascular Benefits: Reduces left ventricular end-diastolic pressure, improves glucose uptake in ischemic heart tissue, and lowers systemic vascular resistance, enhancing cardiac function (4, 5).
  5. Neuroprotective Properties: Mitigates amyloid-beta plaque formation, promotes neuron survival, and supports cognitive function through interactions with brain GLP-1 receptors (6).

Pharmacokinetics
Semaglutide has a long half-life (~165 hours), allowing for once-weekly dosing. This extended duration improves adherence and maintains consistent therapeutic effects (1, 3).

Research Insights

Weight Loss and Obesity Management
  • Clinical studies show that individuals treated with Semaglutide experienced weight reductions of up to 15% over 68 weeks, significantly outperforming placebo groups (2, 3).
  • Enhanced satiety and reduced caloric intake were key drivers of this outcome (2, 3).
Diabetes and Glycemic Control
  • Reduces HbA1c levels by up to 1.5% in Type 2 diabetes, minimizing the risk of long-term complications (1, 3).
  • Improves fasting and postprandial glucose control while preserving beta-cell function (4).
Cardiovascular Health
  • Demonstrated reduction in cardiovascular events in patients with diabetes and obesity (5).
  • Enhances myocardial glucose uptake and reduces ventricular pressure, aiding heart function (4, 5).
Neuroprotective Potential
  • Animal studies indicate that Semaglutide slows amyloid-beta accumulation, enhances spatial memory, and supports neuron survival (6).
  • Emerging research suggests it could delay Alzheimer’s progression, though further studies are needed (6).

Structure

  • Sequence: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Thr-Lys-Lys-Ser-Lys-Gln-Gly-Glu-Leu-Ala-Gln-Gly-Glu-Arg-Arg-Gln-Glu-Lys-Ala-Glu-Arg-Arg-Ser-Asp-Gly-Thr-Phe-Thr-Asn-Ser.
  • Molecular Formula: C187H291N45O59
  • Molecular Weight: 4113.64 g/mol
  • PubChem CID: 11966638

Citations for Semaglutide

Metabolic and Glycemic Regulation
  1. Holst, J. J. From the Incretin Concept and the Discovery of GLP-1 to Today’s Diabetes Therapy. Front Endocrinol, 2019.
  2. Drucker, D. J. Mechanisms of Action and Therapeutic Applications of GLP-1. Cell Metab, 2018.
Weight Loss and Appetite Regulation
  1. Wilding, J. P. H., et al. Once-weekly Semaglutide in Adults with Overweight or Obesity. New Engl J Med, 2021.
Cardiovascular Health
  1. Marso, S. P., et al. Cardiovascular Outcomes in Patients with Type 2 Diabetes on Semaglutide. New Engl J Med, 2016.
  2. Drucker, D. J., et al. GLP-1 Receptor Agonists and Cardiovascular Risk Reduction. Diabetes Care, 2020.
Neuroprotective Research
  1. “Semaglutide and Neurodegenerative Disease,” Diabetes Care Journal, 2020.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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