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Epithalon (Epitalon)

BATCH

PURITY

99% HPLC

  • CAS #:
  • 307297-39-8
  • Formula:
  • C14H22N4O9
  • M.W.:
  • 390.35 g/mol

Epithalon (Epitalon)

Cellular RenewalLongevityTelomerase Activator

From $99.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $99.00
2 - 4 $89.10
5 - 9 $84.15
10 - 14 $79.20
15 - 19 $74.25
20 + $69.30
Only the lyophilized product is provided. All supplies sold separately. For research use only.

Summary

Epithalon (Epitalon) is a synthetic tetrapeptide studied for its role in promoting longevity, cellular repair, and overall health optimization. It is known to activate telomerase, a key enzyme associated with cellular lifespan and longevity. By protecting and extending telomeres—the protective caps of chromosomes—Epithalon may help reduce the effects of aging, improve sleep regulation, and enhance immune resilience.

Description & Pharmacodynamics

Epithalon is derived from epithalamin, a natural peptide produced in the pineal gland. Its primary mechanism of action involves the activation of telomerase, which helps maintain the length and integrity of telomeres¹. Telomere shortening is a hallmark of aging, and by counteracting this process, Epithalon supports cellular health and longevity.

Additionally, Epithalon plays a critical role in regulating the circadian rhythm by stimulating melatonin production². It also exhibits antioxidant properties, protecting cells from oxidative stress and reducing DNA damage³. Research indicates that Epithalon may enhance immune function, promote healthy cell division, and support the repair of damaged tissues⁴.

Research Insights

Longevity and Telomerase Activation

  • Key Findings: Epithalon activates telomerase, maintaining telomere length and supporting cellular longevity.
  • Mechanisms: Increases telomerase activity in somatic cells, delaying senescence¹.
  • Applications: Anti-aging therapies, prevention of age-related diseases, and longevity enhancement.

Circadian Rhythm Regulation

  • Key Findings: Epithalon stimulates melatonin production, improving sleep quality and regulating biological rhythms.
  • Mechanisms: Restores pineal gland function, synchronizing circadian cycles².
  • Applications: Sleep disorders, seasonal affective disorder (SAD), and jet lag recovery.

Antioxidant and DNA Protection

  • Key Findings: Epithalon reduces oxidative stress, prevents DNA damage, and supports cellular repair mechanisms³.
  • Mechanisms: Scavenges free radicals and enhances cellular repair pathways⁴.
  • Applications: Chronic inflammation, oxidative stress conditions, and DNA damage-related disorders.

Structure

  • Sequence: Ala-Glu-Asp-Gly
  • Molecular Formula: C₁₀H₁₆N₂O₈
  • Molecular Weight: ~390.35 Da
  • PubChem CID: 16129637

Citations for Epithalon (Epitalon)

Longevity and Telomerase Activation

  1. Khavinson, V.K. et al. Peptide Regulation of Aging via Telomerase Activation. (2003).
  2. Arutyunyan, A.V. et al. The Role of Epithalon in Telomere Maintenance. (2011).

Circadian Rhythm Regulation

  1. Khavinson, V.K. Epithalon and the Pineal Gland: Implications for Sleep and Aging. (2006).
  2. Semenova, T. et al. Melatonin Production and Sleep Regulation with Epithalon. (2015).

Antioxidant and DNA Protection

  1. Shaposhnikov, M. et al. Epithalon as an Antioxidant and DNA Repair Enhancer. (2017).
  2. Anisimov, V.N. et al. The Protective Role of Epithalon in Oxidative Stress Models. (2009).

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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