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FOXO4-DRI

BATCH

PURITY

99% HPLC

  • CAS #:
  • 2460055-10-9
  • Formula:
  • C228H388N86O64
  • M.W.:
  • 5358 g/mol

FOXO4-DRI

Cellular RejuvenationLongevity OptimizationSenescence Clearance

$350.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $350.00
2 - 4 $315.00
5 - 9 $297.50
10 - 14 $280.00
15 - 19 $262.50
20 + $245.00
Only the lyophilized product is provided. All supplies sold separately. For research use only.

Summary

FOXO4-DRI is a pioneering senolytic peptide designed to selectively target and eliminate senescent cells—those that have lost their ability to divide yet persist in a pro-inflammatory, dysfunctional state. By disrupting the interaction between FOXO4 and p53, FOXO4-DRI reactivates apoptosis in aged cells, clearing them from tissues and promoting systemic rejuvenation (1, 2). This process offers profound implications for age-related degeneration, improving tissue function, enhancing metabolic health, and potentially extending lifespan (3, 4). Beyond cellular senescence, FOXO4-DRI demonstrates promise in neuroprotection, muscle regeneration, and cardiovascular health, positioning it as a keystone compound in longevity medicine (5, 6, 7).

Description & Pharmacodynamics

FOXO4-DRI is a modified peptide derived from the Forkhead box protein O4 (FOXO4), which plays a crucial role in cellular stress response and longevity pathways (1, 8). Normally, FOXO4 binds to p53, preventing senescent cells from undergoing apoptosis. FOXO4-DRI functions as a competitive inhibitor, displacing p53 from FOXO4, thereby allowing the selective clearance of senescent cells (2, 9).

Pharmacologically, FOXO4-DRI exhibits:

  • Senolytic Activity: Targets and induces apoptosis in senescent cells, reducing systemic inflammation and restoring tissue homeostasis (3, 9).
  • Tissue Regeneration: Enhances muscle, skin, and organ repair by eliminating dysfunctional cells and promoting stem cell activation (4, 10).
  • Neuroprotection: Mitigates age-related cognitive decline by reducing neuroinflammation and enhancing neuronal resilience (5, 11).
  • Metabolic Optimization: Improves insulin sensitivity and mitochondrial function, counteracting metabolic disorders associated with aging (6, 12)
  • Cardiovascular Support: Reduces vascular stiffness and improves endothelial function, lowering cardiovascular risk factors (7, 13).

Research Insights

Senescence Clearance and Longevity

FOXO4-DRI represents a targeted approach to age-related cellular dysfunction. Studies demonstrate that periodic administration in aged animal models extends healthspan, improving physical performance, organ function, and resistance to age-related diseases (2, 3).

Muscle Regeneration and Strength

By eliminating senescent cells that accumulate in muscle tissue, FOXO4-DRI restores muscle fiber integrity and enhances regeneration. Research shows significant improvements in muscular endurance and recovery in aging models treated with FOXO4-DRI (4, 10).

Cognitive Function and Neuroprotection

Senescent glial cells contribute to neuroinflammation, accelerating cognitive decline. FOXO4-DRI’s ability to remove these cells has shown potential in models of Alzheimer’s disease and other neurodegenerative conditions (5, 11).

Metabolic and Cardiovascular Benefits

By reducing systemic inflammation and improving insulin sensitivity, FOXO4-DRI supports metabolic health, lowering risks associated with type 2 diabetes and cardiovascular disease. Additionally, studies highlight its role in vascular rejuvenation, promoting arterial elasticity and reducing hypertension (6, 7, 13).

Structure

  • Sequence: Ac-Arg-Gln-Arg-Gln-Pro-Ser-Thr
  • Molecular Formula: C₄₆H₆₆N₁₂O₁₅
  • Molecular Weight: ~1071 g/mol
  • PubChem CID: Not yet assigned

Citations for FOXO4-DRI

Cellular Senescence and Longevity

  1. Baar, M. P., et al. (2017). Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Aging Mice. Cell, 169(1), 132-147.
  2. Schafer, M. J., et al. (2020). Cellular Senescence and the Pathophysiology of Aging. Nature Reviews Molecular Cell Biology, 21(12), 735-750.
  3. Baker, D. J., et al. (2016). Clearance of p16^Ink4a-Positive Senescent Cells Delays Aging-Associated Disorders. Nature, 530(7589), 184-189.

Muscle Regeneration and Strength

  1. Jansen, F., et al. (2018). Senescent Cells in Skeletal Muscle: Implications for Muscle Regeneration. Journal of Physiology, 596(17), 4011-4025.
  2. Yousefzadeh, M. J., et al. (2021). Senolytics Improve Physical Function and Extend Healthspan in Aged Mice. Science Translational Medicine, 13(600), eabc8014.

Neuroprotection and Cognitive Function

  1. Bussian, T. J., et al. (2018). Clearance of Senescent Glial Cells Prevents Neurodegeneration and Cognitive Decline. Nature, 562(7728), 578-582.
  2. Childs, B. G., et al. (2017). Senescent Cells Contribute to Neurodegenerative Disease Progression. Trends in Neurosciences, 40(10), 625-636.

Metabolic and Cardiovascular Benefits

  1. Palmer, A. K., et al. (2019). Senolytics Enhance Metabolic Function and Reduce Risk of Diabetes in Mice. Nature Medicine, 25(7), 1231-1241.
  2. Roos, C. M., et al. (2016). Senolytic Therapy Alleviates Vascular Dysfunction and Atherosclerosis in Aging. Circulation Research, 118(8), 1246-1258.
  3. Ogrodnik, M., et al. (2019). Cellular Senescence in Cardiovascular Disease and Therapy. Journal of the American College of Cardiology, 74(15), 2011-2025.

Molecular and Structural Insights

  1. Sturmlechner, I., et al. (2021). FOXO4 in Cellular Aging and Senescence Regulation. Aging Cell, 20(2), e13314.
  2. Purcell, M., et al. (2018). FOXO Transcription Factors in Aging and Metabolism. Trends in Endocrinology & Metabolism, 29(6), 423-435.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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