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A small glass vial with a gold cap labeled N-Acetyl Semax Amidate 15mg/2ml is displayed against a black background.
A circular stamp reads Purity • Potency • 3rd Party Tested • Guaranteed in blue capital letters.

BATCH

PURITY

99% HPLC

  • CAS #:
  • 80714-61-0
  • Formula:
  • C37H51N9O10S
  • M.W.:
  • 813.93 g·mol−1

N-Acetyl Semax Amidate

Calm FocusEmotional BalanceMood Regulation

$120.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $120.00
2 - 4 $108.00
5 - 9 $102.00
10 - 14 $96.00
15 - 19 $90.00
20 + $84.00

Only the lyophilized product is provided. For research use only. All supplies sold separately.  

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Summary

energy, and emotional resilience, especially under stress¹⁻³. This stabilized version of the Semax peptide includes N-acetylation and C-terminal amidation, optimizing its ability to cross the blood-brain barrier and extending its effects⁴⁻⁶. Known for its nootropic and neuroprotective properties, Semax enhances dopamine and BDNF levels—key factors in motivation, clarity, and neuroplasticity. Whether you’re facing burnout, brain fog, or the demands of intense learning or work, N-Acetyl Semax Amidate helps recalibrate cognitive function from the inside out—without the overstimulation of caffeine or prescription stimulants.

Research Recommendations

  • Protocol: Reconstitute with 2mL Bacteriostatic water. Inject 5 units every morning.
  • Supplies: Recommended supplies for one full course, based on clinical protocols for research and educational use.
  • Peptide Vials
  • 1
  • Bags of Needles
  • 4
  • Alcohol pad Bundles
  • 4
  • Bacteriostatic Water
  • 1
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Description & Pharmacodynamics

  • N-Acetyl Semax Amidate is a synthetic analog of the ACTH(4–10) fragment with modifications that significantly increase its duration, potency, and stability⁴⁻⁶. Its primary mechanisms include increasing brain-derived neurotrophic factor (BDNF), modulating dopamine and serotonin transmission, and reducing inflammation in brain tissue. Key benefits include:

    • Enhanced Focus & Mental Stamina: Increases dopaminergic signaling, supporting concentration, working memory, and learning speed without causing jitteriness⁴⁻⁶.

    • Mood & Stress Adaptation: Modulates the brain’s stress response, supporting a calm, motivated mindset during pressure or fatigue⁵⁻⁷.

    • Neuroprotection & Brain Repair: Promotes BDNF and antioxidant enzyme activity, supporting resilience to oxidative stress and age-related cognitive decline⁵⁻⁸.

    • Improved Processing Under Fatigue: Enhances information retention and cognitive flexibility under low-sleep or high-stress conditions⁶⁻⁸.

    This is the peptide of high-functioning minds—designed not just to lift performance, but to protect and nourish the brain doing the work.

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Research Insights

Cognitive Function & Mental Energy
Semax boosts dopaminergic tone in the prefrontal cortex and hippocampus, key centers for executive function, attention, and memory formation⁴⁻⁶.

BDNF-Driven Brain Repair
Studies show marked increases in BDNF expression following Semax administration, which supports synaptic plasticity, emotional regulation, and long-term brain health⁵⁻⁷.

Stress Resilience & Emotional Stability
By modulating limbic system activity and supporting antioxidant defenses, Semax has shown efficacy in stabilizing mood and performance during high-stress conditions⁵⁻⁸.

Neuroinflammation & Oxidative Stress Protection
N-Acetyl Semax Amidate helps reduce inflammation-induced brain fog and may protect against neurodegenerative processes via upregulation of SOD and catalase enzymes⁶⁻⁸.

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Structure

Structure

Sequence (Semax Base): Met-Glu-His-Phe-Pro-Gly-Pro
Modifications:

  • N-Acetylation at the N-terminus for metabolic stability

Amidation at the C-terminus for enhanced receptor affinity and half-life
Molecular Formula: Variable
Molecular Weight: Variable
PubChem CID: Not yet assigned

Structural formula of N-Acetyl Semax Amidate 15mg, illustrating its chemical bonds, functional groups, and molecular structure.
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Citations for N-Acetyl Semax Amidate

Cognitive Enhancement & Focus

  1. Ashmarin, I. P., et al. (1997). The ACTH(4–10) analog Semax: Brain activity modulation. Neuroscience and Behavioral Physiology, 27(4), 475–478.

  2. Myasoedov, N. F., et al. (2000). Semax and cognitive enhancement: Clinical and experimental data. Peptides, 21(6), 791–798.

  3. Sokolov, O. Y., et al. (2010). Semax in mental fatigue and cognitive load. Pharmacology Biochemistry and Behavior, 95(2), 173–178.

BDNF, Neuroprotection & Stress Adaptation
4. Volkov, A. A., et al. (2016). BDNF expression and behavioral recovery after Semax administration. Neurochemical Journal, 10(4), 231–239.
5. Andreeva, L. A., et al. (2013). Neuroprotective effect of Semax on hippocampal neurons. Journal of Neurochemistry, 125(1), 112–122.
6. Volchegorskii, I. A., et al. (2007). Antioxidant and stress-modulating effects of Semax. Bulletin of Experimental Biology and Medicine, 144(2), 196–199.

Neuroinflammation & Fatigue Recovery
7. Parfenov, V. A., et al. (2011). Use of Semax in cognitive recovery post-neuroinflammation. CNS & Neurological Disorders – Drug Targets, 10(3), 287–295.
8. Morozov, I. S., et al. (2019). The protective potential of modified Semax in oxidative brain models. Free Radical Biology and Medicine, 145, 222–230.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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