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SS-31
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BATCH

PURITY

99% HPLC

  • CAS #:
  • 736992-21-5
  • Formula:
  • C32H49N9O5
  • M.W.:
  • 639.8 g/mol

SS-31

Cellular RepairLongevityMuscle Growth & Recovery

$129.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $129.00
2 - 4 $116.10
5 - 9 $109.65
10 - 14 $103.20
15 - 19 $96.75
20 + $90.30

Only the lyophilized product is provided. For research use only. All supplies sold separately.  

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Summary

SS-31 (also known as Elamipretide) is a mitochondria-targeting peptide designed to improve cellular energy production, reduce oxidative stress, and support tissue function in high-demand systems such as muscle, heart, brain, and skin¹⁻³. Unlike general antioxidants, SS-31 acts directly within the mitochondria—the primary site of energy production—helping restore efficiency where cellular performance begins. As mitochondrial function improves, downstream benefits are observed across multiple systems, including enhanced endurance, improved recovery, and more consistent energy output. In parallel, improvements in skin quality—such as tone, texture, and resilience—reflect reduced oxidative stress and improved cellular turnover at the dermal level. These effects position SS-31 as both a performance-support and longevity-focused peptide, with visible and functional benefits emerging together.

Research Recommendations

  • Protocol: 20 units daily for 4-6 weeks.
  • Supplies: Recommended supplies for one full course, based on clinical protocols for research and educational use.
  • Peptide Vials
  • 2-3
  • Bags of Needles
  • 3
  • Alcohol pad Bundles
  • 3
  • Bacteriostatic Water
  • 1
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Description & Pharmacodynamics

SS-31 is a cell-permeable tetrapeptide that selectively targets the inner mitochondrial membrane by binding to cardiolipin, a phospholipid essential for maintaining mitochondrial structure and function¹⁻⁴. This interaction stabilizes the electron transport chain and reduces the production of reactive oxygen species (ROS), improving overall mitochondrial efficiency.

  • Mitochondrial Stabilization: Binds to cardiolipin to preserve cristae structure and optimize electron transport chain activity¹⁻⁴.
  • ATP Production Support: Enhances oxidative phosphorylation, leading to improved cellular energy output across tissues²⁻⁵.
  • Oxidative Stress Reduction: Limits excess ROS production at the mitochondrial level, protecting proteins, lipids, and DNA from damage³⁻⁶.
  • Muscle & Cardiac Function Support: Improves energy availability in high-demand tissues, supporting endurance, strength, and recovery⁴⁻⁷.
  • Skin & Cellular Longevity Effects: Reduces oxidative damage in dermal cells, supporting improved skin appearance through enhanced cellular efficiency and turnover⁶⁻⁸.

SS-31 operates at the level of cellular energy infrastructure, making its effects both foundational and system-wide.

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Research Insights

Mitochondrial Function & Energy Production
SS-31 has been shown to restore mitochondrial respiration and improve ATP generation by stabilizing cardiolipin and reducing electron leak within the electron transport chain¹⁻⁴. This leads to improved energy efficiency in both healthy and stressed cells.

Reduction of Oxidative Stress
By targeting ROS production at its source, SS-31 reduces oxidative damage more effectively than non-targeted antioxidants. This has implications for aging, fatigue, and chronic inflammatory states³⁻⁶.

Muscle Performance & Recovery
Preclinical and clinical studies demonstrate improved muscle function, increased endurance capacity, and reduced fatigue in models of mitochondrial dysfunction and aging⁴⁻⁷.

Cardiovascular & Metabolic Support
SS-31 has shown potential in improving cardiac efficiency and reducing mitochondrial-related dysfunction in cardiovascular tissue, supporting overall metabolic health²⁻⁵.

Skin & Cellular Aging
Mitochondrial dysfunction is a key driver of visible aging. By improving mitochondrial efficiency and reducing oxidative stress, SS-31 supports healthier dermal cell function, contributing to improved skin tone, elasticity, and resilience as part of broader cellular optimization⁶⁻⁸.

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Structure

  • Sequence: D-Arg-2′,6′-dimethylTyr-Lys-Phe-NH₂
  • Peptide Class: Mitochondria-targeting tetrapeptide
  • Molecular Formula: C₃₂H₄₉N₉O₅
  • Molecular Weight: ~639.8 g/mol
  • PubChem CID: 44514835
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Citations for SS-31

    1. Szeto, H. H., & Schiller, P. W. (2011). Novel therapies targeting inner mitochondrial membrane: SS peptides. Pharmacological Reviews, 63(3), 553–566.
    2. Birk, A. V., et al. (2013). Targeting mitochondrial cardiolipin with SS-31 improves bioenergetics. Journal of the American Society of Nephrology, 24(8), 1250–1261.
    3. Zhao, K., et al. (2004). Cell-permeable peptide antioxidants targeting mitochondria. Journal of Biological Chemistry, 279(33), 34682–34690.
    4. Dai, D. F., et al. (2011). Mitochondrial oxidative stress in aging and heart disease. Circulation Research, 108(3), 319–331.
    5. Siegel, M. P., et al. (2013). Mitochondrial-targeted peptide improves metabolism and energy production. PLoS ONE, 8(1), e54859.
    6. Anderson, E. J., et al. (2009). Mitochondrial dysfunction and oxidative stress in aging tissues. American Journal of Physiology, 297(4), H1378–H1387.
    7. Hou, Y., et al. (2018). SS-31 improves skeletal muscle performance and reduces fatigue. Aging Cell, 17(2), e12754
    8. Chacko, B. K., et al. (2014). Mitochondrial bioenergetics and skin aging. Journal of Investigative Dermatology, 134(9), 2349–2358.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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