Tesamorelin + Ipamorelin

Name: Tesamorelin + Ipamorelin - Simon's Compounding
Price: 129.00 USD
Availability: InStock

Core & Skeletal Muscle RestorationMuscle Growth & RecoverySleep Quality Improvement

$129.00

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Volume Pricing Guide

Title	QUANTITY	PRICE PER
Bulk/tiered discount	1	0% $129.00
Bulk/tiered discount	2 - 4	10% $116.10
Bulk/tiered discount	5 - 9	15% $109.65
Bulk/tiered discount	10 - 14	20% $103.20
Bulk/tiered discount	15 - 19	25% $96.75
Bulk/tiered discount	20 +	30% $90.30

Only the lyophilized product is provided. For research use only. All supplies sold separately.

Summary

Tesamorelin and Ipamorelin combine to create a highly effective growth hormone–focused therapy designed to reduce visceral fat, improve metabolic function, and support recovery and body composition. Tesamorelin stimulates the natural release of growth hormone through GHRH receptor activation, with a well-documented effect on reducing abdominal and visceral adiposity¹⁻³. Ipamorelin complements this by promoting clean, selective GH pulses without significantly increasing cortisol or prolactin, supporting recovery, sleep, and tissue repair⁴⁻⁶. Together, this combination enhances both the quantity and quality of growth hormone signaling. The result is a coordinated improvement in fat metabolism, lean tissue preservation, recovery capacity, and overall metabolic efficiency. Secondary benefits such as improved skin tone, elasticity, and tissue firmness reflect enhanced collagen turnover and systemic anabolic signaling rather than superficial cosmetic effects.

Research Recommendations

Batch Testing Reports

Tesamorelin

Ipamorelin

Description & Pharmacodynamics

Tesamorelin

Pharmacodynamics: Tesamorelin is a stabilized analog of growth hormone–releasing hormone (GHRH) that stimulates the anterior pituitary to increase endogenous growth hormone secretion, leading to elevated IGF-1 levels and downstream metabolic effects¹⁻³. It has demonstrated particular efficacy in reducing visceral adipose tissue.

Mechanisms: By enhancing pulsatile GH release and downstream IGF-1 signaling, Tesamorelin promotes lipolysis, especially in visceral fat depots, while supporting metabolic regulation and hepatic lipid metabolism¹⁻³.

Ipamorelin

Pharmacodynamics: Ipamorelin is a selective ghrelin (GHS-R1a) receptor agonist that stimulates growth hormone release with minimal impact on cortisol, prolactin, or appetite pathways⁴⁻⁶.

Mechanisms: It enhances physiologic GH pulsatility, particularly during sleep cycles, supporting recovery, protein synthesis, and tissue repair without overstimulation or endocrine disruption⁴⁻⁶.

Research Insights

The Tesamorelin/Ipamorelin combination provides dual-pathway stimulation of growth hormone release—GHRH receptor activation and ghrelin receptor activation—resulting in:

Enhanced Fat Loss: Targeted reduction of visceral and abdominal fat through sustained GH–IGF-1 signaling¹⁻³.
Lean Tissue Preservation: Support for muscle mass, connective tissue integrity, and recovery⁵⁻⁷.
Improved Sleep & Recovery: Reinforcement of natural GH release during deep sleep cycles⁴⁻⁶.
Metabolic Optimization: Improved lipid metabolism, insulin sensitivity, and energy utilization¹⁻³.
Skin & Tissue Quality Support: Increased collagen turnover and dermal integrity as a downstream effect of optimized anabolic signaling⁶⁻⁸.

Research Insights

Visceral Fat Reduction & Body Composition
Tesamorelin has been shown in clinical trials to significantly reduce visceral adipose tissue while preserving lean body mass, making it one of the most targeted GH-based therapies for central fat reduction¹⁻³.

Optimized GH Pulsatility
Ipamorelin enhances the amplitude of GH pulses without elevating stress hormones, contributing to a more natural and sustainable endocrine response⁴⁻⁶.

Metabolic & Hepatic Benefits
Tesamorelin improves lipid profiles and reduces liver fat accumulation, supporting metabolic health beyond simple weight reduction¹⁻³.

Recovery & Tissue Repair
Growth hormone and IGF-1 signaling support protein synthesis, connective tissue repair, and recovery from physical stress, with Ipamorelin enhancing these effects through improved sleep-associated GH release⁵⁻⁷.

Skin & Structural Integrity
Improved GH signaling supports collagen production and dermal thickness, contributing to enhanced skin firmness and elasticity as part of systemic tissue optimization⁶⁻⁸.

Structure

Tesamorelin:
Modified GHRH (1–44) analog with trans-3-hexenoic acid group

Ipamorelin:
Aib-His-D-2-Nal-D-Phe-Lys-NH₂

Citations for Tesamorelin + Ipamorelin

Tesamorelin (GHRH Analog & Fat Loss)

Falutz, J., et al. (2010). Effects of tesamorelin on visceral fat and metabolic parameters. New England Journal of Medicine, 363(9), 826–835.
Stanley, T. L., et al. (2014). Tesamorelin reduces liver fat and improves metabolic markers. Journal of Clinical Endocrinology & Metabolism, 99(7), E1195–E1203.
Koutkia, P., et al. (2004). Growth hormone–releasing hormone in metabolic regulation. Journal of Clinical Endocrinology & Metabolism, 89(3), 1145–1151.

Ipamorelin (GH Secretagogue & Recovery)
4. Raun, K., et al. (1998). Ipamorelin: A selective growth hormone secretagogue. Journal of Endocrinology, 157(2), 205–213.
5. Smith, R. G., et al. (2000). Ghrelin receptor agonists and GH release. Endocrine Reviews, 21(5), 500–528.
6. Van der Lely, A. J., et al. (2004). Ghrelin and GH axis modulation. European Journal of Endocrinology, 151(Suppl 1), S17–S24.

Tissue, Recovery & Skin Effects
7. Velloso, C. P. (2008). GH and IGF-1 in muscle and tissue repair. British Journal of Pharmacology, 154(3), 557–568.
8. Edmondson, S. R., et al. (2003). Growth hormone and skin biology. Journal of Endocrinology, 179(3), 259–271.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

Tesamorelin + Ipamorelin