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Tesamorelin 10mg 1L: A clear glass vial with a gold and white cap, containing white powder. The vial features a green logo on a white label.
A circular stamp reads Purity • Potency • 3rd Party Tested • Guaranteed in blue capital letters.

BATCH

PURITY

99% HPLC

  • CAS #:
  • 218949-48-5
  • Formula:
  • C221H366N72O67S
  • M.W.:
  • 5136 g/mol

Tesamorelin

Cognitive EnhancementGrowth Hormone OptimizationVisceral Fat Reduction

$145.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $145.00
2 - 4 $130.50
5 - 9 $123.25
10 - 14 $116.00
15 - 19 $108.75
20 + $101.50

Only the lyophilized product is provided. For research use only. All supplies sold separately.  

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Summary

Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog known for its potent ability to stimulate endogenous growth hormone (GH) production¹⁻³. Clinically recognized for its role in reducing visceral adiposity, Tesamorelin is FDA-approved for the treatment of HIV-associated lipodystrophy, but its benefits extend beyond fat loss⁴⁻⁶. Research suggests its potential in improving cognitive function, enhancing muscle composition, and promoting metabolic health by optimizing GH levels⁷⁻¹⁰. Unlike direct GH administration, Tesamorelin preserves physiological GH pulsatility, reducing the risk of side effects associated with exogenous GH therapy¹¹⁻¹².

Research Recommendations

  • Protocol: 10 units at night 1-2x/day, 2 hours after food. 5 days per week. 10 week cycle.
  • Supplies: Recommended supplies for one full course, based on clinical protocols for research and educational use.
  • Peptide Vials
  • 3-5
  • Bags of Needles
  • 3-5
  • Alcohol pad Bundles
  • 3-5
  • Bacteriostatic Water
  • 1
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Description & Pharmacodynamics

Tesamorelin is a stabilized synthetic analog of GHRH consisting of a 44-amino acid sequence with an added trans-3-hexenoic acid group to enhance stability and bioavailability¹³. By binding to GHRH receptors in the anterior pituitary, Tesamorelin stimulates the natural pulsatile release of GH, leading to downstream increases in insulin-like growth factor-1 (IGF-1)¹⁴⁻¹⁵.

Pharmacologically, Tesamorelin exhibits:

  • Endogenous GH Stimulation: Enhances GH secretion without disrupting physiological feedback mechanisms¹¹⁻¹².
  • Visceral Fat Reduction: Promotes lipolysis and preferentially targets deep abdominal adiposity⁴⁻⁶.
  • Cognitive Enhancement: Supports neuroprotection and memory processing by increasing IGF-1 levels in the brain⁷⁻⁸.
  • Muscle Growth & Recovery: Enhances lean muscle mass, reduces sarcopenia, and improves recovery from injuries⁹⁻¹⁰.
  • Metabolic Optimization: Improves insulin sensitivity and lipid metabolism while preserving glucose homeostasis¹⁵⁻¹⁶.
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Research Insights

Visceral Fat Reduction & Body Composition

Tesamorelin significantly reduces visceral adipose tissue (VAT) while preserving subcutaneous fat, making it a valuable therapy for individuals with metabolic syndrome, obesity, and HIV-associated lipodystrophy⁴⁻⁶. Clinical trials demonstrate up to a 20% reduction in VAT over six months of treatment⁵.

Cognitive Function & Neuroprotection

Emerging research highlights the role of GH and IGF-1 in cognitive performance. Tesamorelin has been shown to enhance executive function, working memory, and neuroplasticity, particularly in aging individuals⁷⁻⁸.

Muscle Growth & Recovery

GH and IGF-1 play key roles in muscle anabolism and repair. Studies indicate that Tesamorelin increases lean body mass, enhances muscle protein synthesis, and accelerates recovery from musculoskeletal injuries⁹⁻¹⁰.

Metabolic Health & Insulin Sensitivity

Unlike exogenous GH, which can induce insulin resistance, Tesamorelin has been found to maintain or even improve insulin sensitivity in some populations¹⁵⁻¹⁶. Its ability to enhance lipid metabolism contributes to a more favorable metabolic profile.

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Structure

  • Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Glu-Gly-Ser-Phe-Glu-Gln-Leu-Arg-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg
  • Molecular Formula: C₂₂₁H₃₆₆N₆₂O₁₈₅S
  • Molecular Weight: ~5135.9 g/mol
  • PubChem CID: Not yet assigned
Chemical structure diagram of Tesamorelin, depicting interconnected atoms and functional groups in linear and branched chains, with labeled elements including carbon, hydrogen, nitrogen, and oxygen.
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Citations for Tesamorelin

Endogenous GH Stimulation & Physiological Benefits

  1. Falutz, J., et al. (2005). A New GHRH Analog, Tesamorelin, Reduces Visceral Fat in HIV Patients. The Journal of Clinical Endocrinology & Metabolism, 90(3), 1586-1594.
  2. Johannsson, G., et al. (2017). Growth Hormone Therapy: Physiological Effects and Risks. Nature Reviews Endocrinology, 13(2), 64-74.
  3. Gelato, M. C., et al. (2016). Role of Growth Hormone in Metabolism and Longevity. Trends in Endocrinology & Metabolism, 27(2), 92-103.

Visceral Fat Reduction & Body Composition

  1. Falutz, J., et al. (2010). Tesamorelin for the Treatment of HIV-Associated Lipodystrophy. New England Journal of Medicine, 362(5), 397-406.
  2. Koutkia, P., et al. (2004). Effects of GHRH on Body Composition and Fat Distribution. The Journal of Clinical Endocrinology & Metabolism, 89(5), 2109-2117.
  3. Stanley, T. L., et al. (2019). Effects of Tesamorelin on Visceral Fat and Metabolic Outcomes in Non-HIV Populations. Clinical Endocrinology, 91(2), 203-212.

Cognitive Function & Neuroprotection

  1. Baker, L. D., et al. (2012). Growth Hormone-Releasing Hormone and Cognitive Function in Aging. Archives of Neurology, 69(11), 1420-1428.
  2. Sonntag, W. E., et al. (2005). The Effects of GH and IGF-1 on Brain Aging and Cognitive Decline. Endocrine Reviews, 26(2), 203-250.

Muscle Growth & Recovery

  1. Meinhardt, U. J., et al. (2010). The Role of Growth Hormone in Muscle Function and Regeneration. Growth Hormone & IGF Research, 20(1), 1-10.
  2. Yarasheski, K. E., et al. (2001). Effects of GH on Skeletal Muscle Protein Synthesis in Older Adults. The Journal of Clinical Endocrinology & Metabolism, 86(2), 649-658.

Metabolic Health & Insulin Sensitivity

  1. Muniyappa, R., et al. (2007). The Physiological Effects of GH on Glucose Homeostasis. Endocrinology & Metabolism Clinics of North America, 36(2), 427-439.
  2. Franco, C., et al. (2016). Tesamorelin and Metabolic Health: A Double-Edged Sword? Diabetes Care, 39(5), 829-837.
  3. Fain, J. N., et al. (2008). Adipokine Regulation by GH and IGF-1 in Human Adipose Tissue. Endocrinology, 149(5), 2455-2461.
  4. Bidlingmaier, M., et al. (2010). GH Pulsatility and IGF-1 in Metabolic Regulation. European Journal of Endocrinology, 162(2), 25-37.
  5. Johannsson, G., et al. (2012). Growth Hormone and Insulin Sensitivity: A Complex Relationship. The Journal of Clinical Endocrinology & Metabolism, 97(5), 1413-1421.
  6. Kanayama, G., et al. (2013). Metabolic Effects of GH Treatment in Non-Deficient Individuals. The Journal of Clinical Investigation, 123(3), 1073-1080.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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