GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) naturally increases in youthful skin and declines with age. It plays a critical role in activating genes responsible for collagen synthesis, skin tightening, and antioxidant defense⁵⁻⁷. BPC-157 supports this function by modulating inflammatory pathways, promoting microvascular regeneration, and accelerating epithelial turnover⁸⁻¹⁰. When applied together:
A daily ritual of renewal, this cream isn’t just skincare—it’s an intimate dialogue with the body’s memory of youth.
Collagen Renewal & Skin Texture Improvement
GHK-Cu stimulates fibroblast activity and upregulates key regenerative genes, including TGF-β and VEGF, supporting improved skin firmness, elasticity, and youthful volume⁵⁻⁷. BPC-157 complements this by accelerating cell turnover and supporting dermal matrix cohesion⁸⁻¹⁰.
Wrinkle Reduction & Antioxidant Defense
Studies confirm GHK-Cu reduces oxidative stress, inhibits MMPs that break down collagen, and enhances glycosaminoglycan production, key for plump and hydrated skin⁶⁻⁷. BPC-157 further decreases oxidative damage and calms inflammatory mediators for smoother, less reactive skin⁸.
Hair Density & Scalp Health
GHK-Cu has been shown to reactivate dormant follicles and extend the anagen (growth) phase of the hair cycle¹². Combined with BPC-157’s angiogenic and anti-inflammatory effects, the duo revitalizes the scalp microenvironment and supports visible hair thickening¹³.
Synergy with Dermal Rolling
Dermal rolling (microneedling) creates microchannels that significantly improve topical peptide absorption. Clinical studies demonstrate enhanced collagen induction and increased hair follicle nutrient delivery when GHK-Cu/BPC-157 cream is used post-rolling¹¹.
GHK-Cu Sequence: Gly-His-Lys-Cu²⁺ Complex
BPC-157 Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula: Variable
Molecular Weight: Variable
PubChem CID: GHK-Cu (CID 440217); BPC-157 (CID Not Assigned)
Skin Rejuvenation & Aesthetic Enhancement
Antioxidant & Anti-Inflammatory Effects
4. Gampel, A., et al. (2022). GHK-Cu improves oxidative defense in aging skin. Journal of Investigative Dermatology, 142(5), 1273–1282.
5. Sikiric, P., et al. (2020). BPC 157 in topical regeneration and oxidative stress modulation. Wound Repair and Regeneration, 28(3), 395–404.
Hair Regrowth Support
6. Pickart, L. (2008). Hair follicle stimulation by copper peptides. Journal of the American Academy of Dermatology, 59(3), AB122.
7. Kang, J. W., et al. (2021). Peptide-based therapy for hair regrowth: GHK-Cu in androgenic alopecia. Journal of Cosmetic Dermatology, 20(3), 893–900.
Synergy with Dermal Rolling
8. Aust, M. C., et al. (2008). Percutaneous collagen induction therapy: Microneedling enhances topical active delivery. Plastic and Reconstructive Surgery, 121(4), 1421–1429.
9. Fernandez, J. L. (2015). Combination of microneedling and copper peptides for hair and skin rejuvenation. Journal of Aesthetic Nursing, 4(5), 220–227.
10. Jeong, K. H., et al. (2017). Microneedling with peptide complexes for scalp regeneration: A pilot study. International Journal of Trichology, 9(3), 129–134.
Copper Topical Pairings: Longevity Stack, “GHK-cu 35mg, TB-500 10mg”, Tirzepetide.
**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.