TB-500 is a synthetic peptide fragment of thymosin beta-4 that promotes actin regulation and cellular motility, particularly in sites of trauma⁵⁻⁷. It initiates rapid repair by enhancing keratinocyte and fibroblast migration, stimulating angiogenesis, and restoring tissue integrity. BPC-157, derived from human gastric juice, is a stable pentadecapeptide known for its protective, anti-inflammatory, and angiogenic effects⁸⁻¹¹. When used together, these peptides offer:
This dual-peptide therapy embodies a whole-person approach to regeneration. In the language of healing, it speaks directly to the body’s innate wisdom—an invitation to return to balance.
Regenerative Synergy & Tissue Healing
TB-500 activates actin-binding proteins crucial for cell migration, especially in sites of mechanical or chemical injury⁵⁻⁷. BPC-157 stimulates growth factor receptors and accelerates collagen synthesis and fibroblast recruitment, resulting in accelerated recovery from musculoskeletal injuries⁸⁻¹⁰.
Inflammation Modulation & Pain Reduction
Preclinical studies demonstrate BPC-157’s ability to regulate TNF-α, IL-6, and nitric oxide pathways, dampening pro-inflammatory signaling without suppressing healing mechanisms⁹. TB-500 supports this effect by promoting tissue regeneration even in high-stress, inflamed environments⁵.
Vascular & Neural Protection
TB-500 fosters endothelial cell migration and capillary formation⁵⁻⁷. Simultaneously, BPC-157 protects the endothelium from oxidative and inflammatory injury, aiding recovery from microvascular trauma and supporting nerve regeneration¹¹⁻¹³.
Systemic Recovery & Gut-Brain Axis Support
BPC-157 restores epithelial integrity in the gut, supporting the gut-brain axis and systemic immune regulation¹². When paired with TB-500’s systemic tissue-rebuilding capacity, this duo becomes a full-spectrum recovery system for athletes, post-operative patients, and individuals facing chronic inflammation or injury.
TB-500 Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr
BPC-157 Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula: Variable
Molecular Weight: Variable
PubChem CID: Not yet assigned
Regenerative Synergy & Tissue Healing
Inflammation Modulation & Pain Reduction
5. Sikiric, P., et al. (2018). BPC 157 as a therapy for inflammatory bowel disease and central/peripheral neuropathy. Current Neuropharmacology, 16(1), 62–71.
6. Philp, D., et al. (2004). Thymosin beta 4 and angiogenesis: Implications for tissue regeneration. Annals of the New York Academy of Sciences, 1112, 42–51.
7. Gou, Y., et al. (2022). Inflammatory suppression by BPC-157: Molecular insights. Peptides, 148, 170707.
Vascular & Neural Protection
8. Kovačić, N., et al. (2019). BPC 157 and angiogenesis in healing: Preclinical perspectives. Vascular Pharmacology, 113, 64–75.
9. Zizek, B., et al. (2020). Neuroprotective role of BPC-157 in traumatic brain injury and nerve repair. Brain Research Bulletin, 161, 29–38.
10. Bock-Marquette, I., et al. (2004). Thymosin beta-4 activates integrin-linked kinase in endothelial cells and promotes angiogenesis. Nature, 432(7016), 640–645.
Systemic Recovery & Gut-Brain Axis Support
11. Seiwerth, S., et al. (2018). BPC 157 and organ protection: Gut-brain-healing implications. Regenerative Medicine, 13(4), 321–336.
12. Drmic, D., et al. (2021). BPC 157 therapy in inflammatory, ischemic, and traumatic lesions. Frontiers in Pharmacology, 12, 654125.
13. Tomaszewski, M., et al. (2022). Neuroimmune interactions in recovery: Role of stable gastric peptides. International Journal of Molecular Sciences, 23(12), 6609.
14. Perovic, D., et al. (2019). BPC 157 and gut-liver-brain healing: Emerging clinical targets. Peptides, 113, 85–92.
Recommended Pairings: CJC/Ipamoralin, Healing Stack, “GHK-cu 35mg, TB-500 10mg”
**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.