Semaglutide
Weight Loss | Metabolic Efficiency | Glucose Regulation | Appetite Reshaping
Semaglutide is a synthetic analogue of the naturally occurring glucagon-like peptide-1 (GLP-1), which plays a critical role in regulating glucose metabolism, appetite, and energy balance (1, 2). As the active ingredient in groundbreaking therapies like Ozempic, Wegovy, and others, Semaglutide has transformed the treatment landscape for diabetes and obesity. In clinical trials, individuals receiving Semaglutide achieved weight loss of up to 15% of total body weight over 68 weeks when combined with lifestyle interventions (2, 3). Its mechanisms extend beyond glucose control, offering cardiovascular and potential neuroprotective benefits. By harmonizing metabolic and systemic functions, Semaglutide empowers patients to move toward improved health and vitality, fostering confidence in its therapeutic promise.
*Only the lyophilized peptides will be provided.
Weight Loss | Metabolic Efficiency | Glucose Regulation | Appetite Reshaping
Semaglutide is a synthetic analogue of the naturally occurring glucagon-like peptide-1 (GLP-1), which plays a critical role in regulating glucose metabolism, appetite, and energy balance (1, 2). As the active ingredient in groundbreaking therapies like Ozempic, Wegovy, and others, Semaglutide has transformed the treatment landscape for diabetes and obesity. In clinical trials, individuals receiving Semaglutide achieved weight loss of up to 15% of total body weight over 68 weeks when combined with lifestyle interventions (2, 3). Its mechanisms extend beyond glucose control, offering cardiovascular and potential neuroprotective benefits. By harmonizing metabolic and systemic functions, Semaglutide empowers patients to move toward improved health and vitality, fostering confidence in its therapeutic promise.
*Only the lyophilized peptides will be provided.
Weight Loss | Metabolic Efficiency | Glucose Regulation | Appetite Reshaping
Semaglutide is a synthetic analogue of the naturally occurring glucagon-like peptide-1 (GLP-1), which plays a critical role in regulating glucose metabolism, appetite, and energy balance (1, 2). As the active ingredient in groundbreaking therapies like Ozempic, Wegovy, and others, Semaglutide has transformed the treatment landscape for diabetes and obesity. In clinical trials, individuals receiving Semaglutide achieved weight loss of up to 15% of total body weight over 68 weeks when combined with lifestyle interventions (2, 3). Its mechanisms extend beyond glucose control, offering cardiovascular and potential neuroprotective benefits. By harmonizing metabolic and systemic functions, Semaglutide empowers patients to move toward improved health and vitality, fostering confidence in its therapeutic promise.
*Only the lyophilized peptides will be provided.
Research Insights
Weight Loss and Obesity Management
Clinical studies show that individuals treated with Semaglutide experienced weight reductions of up to 15% over 68 weeks, significantly outperforming placebo groups (2, 3).
Enhanced satiety and reduced caloric intake were key drivers of this outcome (2, 3).
Diabetes and Glycemic Control
Reduces HbA1c levels by up to 1.5% in Type 2 diabetes, minimizing the risk of long-term complications (1, 3).
Improves fasting and postprandial glucose control while preserving beta-cell function (4).
Cardiovascular Health
Demonstrated reduction in cardiovascular events in patients with diabetes and obesity (5).
Enhances myocardial glucose uptake and reduces ventricular pressure, aiding heart function (4, 5).
Neuroprotective Potential
Animal studies indicate that Semaglutide slows amyloid-beta accumulation, enhances spatial memory, and supports neuron survival (6).
Emerging research suggests it could delay Alzheimer’s progression, though further studies are needed (6).
Description & Pharmacodynamics
Mechanisms of Action
Glucose Regulation: Enhances insulin secretion in a glucose-dependent manner while suppressing glucagon release, reducing hepatic glucose production, and stabilizing blood sugar levels (1, 3).
Appetite Suppression and Weight Loss: By activating GLP-1 receptors in the hypothalamus and brainstem, Semaglutide increases satiety, slows gastric emptying, and reduces caloric intake (2, 3).
Beta Cell Protection: Promotes pancreatic beta cell growth, proliferation, and protection from apoptosis, supporting insulin production and pancreatic health (4).
Cardiovascular Benefits: Reduces left ventricular end-diastolic pressure, improves glucose uptake in ischemic heart tissue, and lowers systemic vascular resistance, enhancing cardiac function (4, 5).
Neuroprotective Properties: Mitigates amyloid-beta plaque formation, promotes neuron survival, and supports cognitive function through interactions with brain GLP-1 receptors (6).
Pharmacokinetics
Semaglutide has a long half-life (~165 hours), allowing for once-weekly dosing. This extended duration improves adherence and maintains consistent therapeutic effects (1, 3).
Structure
Sequence: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Thr-Lys-Lys-Ser-Lys-Gln-Gly-Glu-Leu-Ala-Gln-Gly-Glu-Arg-Arg-Gln-Glu-Lys-Ala-Glu-Arg-Arg-Ser-Asp-Gly-Thr-Phe-Thr-Asn-Ser.
Molecular Formula: C187H291N45O59
Molecular Weight: 4113.64 g/mol
PubChem CID: 11966638
Citations
Metabolic and Glycemic Regulation
Holst, J. J. From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy. Front Endocrinol, 2019.
Drucker, D. J. Mechanisms of Action and Therapeutic Applications of GLP-1. Cell Metab, 2018.
Weight Loss and Appetite Regulation
Wilding, J. P. H., et al. Once-weekly Semaglutide in Adults with Overweight or Obesity. New Engl J Med, 2021.
Cardiovascular Health
Marso, S. P., et al. Cardiovascular Outcomes in Patients with Type 2 Diabetes on Semaglutide. New Engl J Med, 2016.
Drucker, D. J., et al. GLP-1 Receptor Agonists and Cardiovascular Risk Reduction. Diabetes Care, 2020.
Neuroprotective Research
"Semaglutide and Neurodegenerative Disease," Diabetes Care Journal, 2020.
