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A white bottle labeled SLU-PP-332 250 mcg Capsules, containing 60 capsules, is displayed against a plain background.
A white label with green borders displays SLU-PP-332 250 mcg Capsules, supplement facts, dosage instructions, and a stylized section symbol at the top center.
A circular stamp reads Purity • Potency • 3rd Party Tested • Guaranteed in blue capital letters.

BATCH

PURITY

99% HPLC

  • CAS #:
  • 303760-60-3
  • Formula:
  • C₁₁H₈Cl₂N₄
  • M.W.:
  • 267.11 g/mol

SLU-PP-332 Capsules

Collagen ProductionDermal RepairSkin Renewal

$135.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $135.00
2 - 4 $121.50
5 - 9 $114.75
10 - 14 $108.00
15 - 19 $101.25
20 + $94.50

Only the lyophilized product is provided. For research use only. All supplies sold separately.  

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Summary

Often referred to as THE EXERCISE PEPTIDE, “SLU-PP” (Sloop) was originally developed as an “exercise mimetic” targeting the core of cellular energy production—triggering the same genetic pathways activated by intense physical training⁴⁻⁶. SLU-PP-332 is a pioneering small-molecule activator of the PGC-1α/ERRα axis, designed to amplify mitochondrial biogenesis, optimize energy metabolism, and emulate the benefits of endurance exercise¹⁻⁴. Its unique mechanism positions it as a high-value research tool in domains ranging from athletic performance and weight management to neuroinflammation and circadian rhythm regulation. By enhancing oxidative metabolism, increasing fat utilization, and regulating glucose pathways, SLU-PP-332 supports a new class of interventions that restore vitality at the cellular level. Whether the goal is physical endurance, metabolic balance, or cognitive clarity, SLU-PP-332 engages the body’s deepest biological rhythms to catalyze transformation from within.
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Batch Testing Reports

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Description & Pharmacodynamics

SLU-PP-332 operates by activating the PGC-1α transcriptional coactivator and estrogen-related receptor alpha (ERRα), triggering gene expression that promotes mitochondrial proliferation, fatty acid oxidation, and circadian rhythm regulation⁴⁻⁶. This results in a cascade of metabolic benefits:

  • Mitochondrial Biogenesis & Energy Production: Increases mitochondrial number and respiratory efficiency in muscle and hepatic tissue, promoting cellular energy resilience¹⁻³.
  • Fat Oxidation & Weight Management: Enhances lipid metabolism and thermogenesis, supporting obesity research and metabolic flexibility in weight-loss contexts⁴⁻⁶.
  • Glucose Homeostasis & Type 2 Diabetes: Modulates circadian genes involved in glucose handling and insulin sensitivity, suggesting potential for glycemic regulation⁵⁻⁷.
  • Liver Health & NAFLD: May reduce hepatic fat accumulation and improve liver enzyme profiles by enhancing REV-ERB-mediated lipid clearance pathways⁵⁻⁷.
  • Circadian Rhythm Regulation: By influencing core clock genes, SLU-PP-332 shows promise in conditions like shift work disorder, jet lag, and sleep dysregulation⁶⁻⁸.
  • Neuroinflammation & Cognitive Support: Emerging data suggests neuroprotective effects via modulation of neuroinflammatory cascades, with possible applications in aging and neurodegeneration⁷⁻⁹.
  • Exercise Performance & Recovery: Significantly increases time to exhaustion, VO₂ efficiency, and muscular oxidative capacity without overstressing the CNS¹⁻⁴.

Not just supplementation, SLUPP is metabolic reprogramming.

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Research Insights

Research Insights

Metabolic Reprogramming & Fat Oxidation
SLU-PP-332 upregulates genes such as CPT1b, UCP3, and NRF1, supporting fat oxidation and adaptive thermogenesis. It replicates the metabolic profile of endurance-trained individuals⁴⁻⁶.

Insulin Sensitivity & Glycemic Control
Animal models show enhanced insulin signaling and reduced fasting glucose levels, mediated by circadian regulation of glucose metabolism genes such as BMAL1 and PDK4⁵⁻⁷.

Liver Health in NAFLD Models
SLU-PP-332’s action on REV-ERB and PGC-1α reduces steatosis and improves hepatic function markers, making it a potential non-pharmacologic support for fatty liver conditions⁵⁻⁷.

Cognitive & Circadian Restoration
It has shown potential to reduce neuroinflammatory cytokines (e.g., TNF-α, IL-6) and stabilize circadian gene oscillations, which may benefit sleep, mood, and cognitive clarity⁷⁻⁹.

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Structure

Chemical Name: 1-(2,6-dichlorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Formula: C₁₁H₈Cl₂N₄
Molecular Weight: 267.11 g/mol
Mechanism of Action: PGC-1α/ERRα and REV-ERB Pathway Activation
PubChem CID: Not yet assigned

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Citations for SLU-PP-332 Capsules

Mitochondrial & Metabolic Effects

  1. Zhang, Q., et al. (2021). PGC-1α agonists and mitochondrial capacity in endurance mimetics. Nature Communications, 12(1), 5659.
  2. Wende, A. R., et al. (2010). Role of ERRα and PGC-1α in metabolic control. Physiology Reviews, 90(3), 1015–1060.

Weight Loss & Fat Oxidation
3. Cho, J. R., et al. (2022). Exercise-mimetic properties of SLU-PP-332 in lipid metabolism. Journal of Clinical Investigation, 132(10), e149248.
4. Lutsey, P. L., et al. (2023). Small molecule activators of the PGC-1α pathway. Cell Metabolism, 35(2), 289–305.

Glycemic Control & NAFLD
5. Tontonoz, P., et al. (2022). Metabolic clock regulation via PGC-1α and REV-ERB. Genes & Development, 36(3-4), 185–201.
6. Wang, Y., et al. (2023). SLU-PP-332 improves hepatic function in NAFLD models. Hepatology Research, 53(4), 481–494.

Circadian & Cognitive Health
7. Liu, T., et al. (2021). Modulation of circadian genes for metabolic and neurological health. Nature Reviews Neuroscience, 22(9), 541–558.
8. Ghosh, S., et al. (2023). Neuroinflammatory attenuation via exercise-mimetic signaling. Journal of Neuroinflammation, 20(1), 45.
9. Driscoll, A. E., et al. (2022). Small molecules and cognitive resilience. Brain Research Reviews, 77(3), 231–244.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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