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Simons PT-141 + Oxytocin + VIP nasal spray bottle, 2mg/2mg/2mg
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BATCH

PURITY

99% HPLC

  • CAS #:
  • 189691-06-3
  • Formula:
  • C50H68N14O10
  • M.W.:
  • 1025.2 g/mol

PT-141 + Oxytocin + VIP Nasal Spray

$69.00

Volume Pricing Guide

QUANTITY PRICE PER
1 $69.00
2 - 4 $62.10
5 - 9 $58.65
10 - 14 $55.20
15 - 19 $51.75
20 + $48.30

Only the lyophilized product is provided. For research use only. All supplies sold separately.  

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Summary

A nasal-spray research blend of three peptides that act on separate pathways linked to sexual arousal: PT-141 (bremelanotide), a melanocortin receptor agonist; oxytocin, a neuropeptide involved in social bonding; and VIP (vasoactive intestinal peptide), a vasodilating neuropeptide. Each compound has been studied on its own; this combination has not been evaluated in published research. Each batch is HPLC-tested, with the COA available by lot number at simonsrx.com/coa. For laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
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Description & Pharmacodynamics

  • PT-141 (bremelanotide): agonist at melanocortin receptors MC4R and MC1R; acts on central nervous system pathways rather than on blood flow (1, 2).
  • Oxytocin: binds oxytocin receptors in the brain and periphery; plasma levels rise during sexual response in humans (3, 4).
  • VIP: binds VPAC1 and VPAC2 receptors; relaxes smooth muscle and increases local blood flow, including in genital tissue (5, 6).
  • Format: intranasal delivery has been studied for PT-141 and oxytocin (2, 4).
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Research Insights

  1. Bremelanotide was evaluated in two phase 3 trials in premenopausal women with hypoactive sexual desire disorder, with improvements in desire scores versus placebo (1). It is FDA-approved for that use as Vyleesi, an injectable.
  2. An intranasal form of PT-141 produced dose-related erectile responses in a placebo-controlled study in men (2).
  3. Plasma oxytocin rose during sexual arousal and peaked at orgasm in a study of men and women (3); intranasal oxytocin has been studied widely for its effects on social behavior (4).
  4. VIP has been studied as a neurotransmitter in penile erection (5) and induced vaginal lubrication when infused in healthy women (6).
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Structure

PT-141 (Bremelanotide)
  • Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
  • Molecular Formula: C50H68N14O10
  • Molecular Weight: 1025.2 g/mol
  • CAS: 189691-06-3
Oxytocin
  • Sequence: Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (disulfide Cys1–Cys6)
  • Molecular Formula: C43H66N12O12S2
  • Molecular Weight: 1007.2 g/mol
  • CAS: 50-56-6
VIP (Vasoactive Intestinal Peptide)
  • Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
  • Molecular Formula: C147H238N44O42S
  • Molecular Weight: 3325.8 g/mol
  • CAS: 40077-57-4
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Citations for PT-141 + Oxytocin + VIP Nasal Spray

  1. Kingsberg SA, Clayton AH, Portman D, et al. Bremelanotide for the treatment of hypoactive sexual desire disorder: two randomized phase 3 trials. Obstet Gynecol. 2019;134(5):899–908.
  2. Diamond LE, Earle DC, Rosen RC, et al. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Int J Impot Res. 2004;16(1):51–59.
  3. Carmichael MS, Humbert R, Dixen J, et al. Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab. 1987;64(1):27–31.
  4. MacDonald K, MacDonald TM. The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans. Harv Rev Psychiatry. 2010;18(1):1–21.
  5. Ottesen B, Wagner G, Virag R, Fahrenkrug J. Penile erection: possible role for vasoactive intestinal polypeptide as a neurotransmitter. Br Med J. 1984;288(6410):9–11.
  6. Ottesen B, Pedersen B, Nielsen J, et al. Vasoactive intestinal polypeptide (VIP) provokes vaginal lubrication in normal women. Peptides. 1987;8(5):797–800.

**Note:** This product is intended for research purposes only and not for human consumption. Always consult with a healthcare professional before starting any new supplement or research product.

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